Dra. Andrea Mahn Osses

Institutional Level

• University Counselor (2025 – 2029), University of Santiago de Chile.

• Member of the Commission for the Evaluation of Postgraduate Programs (CEPP) (2019 – 2024). Commission in charge of reviewing, evaluating and providing feedback to all USACH graduate programs during their creation and closure process, and in the accreditation processes.

• Member of the Higher Postgraduate Council (2021 - present).

• Member of the study group of the Food area (2013 – 2016 and 2019 – 2020). Evaluation of internal fundamental research projects.

Faculty Level

• Vice-Dean of Research, Development and Postgraduate Studies, Faculty of Engineering, University of Santiago de Chile (2021 – present).

• President of the Postgraduate Committee of the Faculty of Engineering (2021 – present).

• President of the Research, Development and Innovation Committee of the Faculty of Engineering (2021 – present).

• Director of the Technological Doctorate in Engineering Innovation (2024 – present, program created in 2024).

• Director of the formulation team of the Master's program in Engineering Sciences with a mention in Bioprocesses (2023 – present, program in the process of creation).

• Director of the Master's Program in Engineering Sciences with a mention in Chemical Engineering (2023 – 2025, accredited for 6 years until August 2028).

• Director of the Master's Program in Food Technology (2019 – 2022). Reformulation of the Curriculum and the Internal Regulations of the Program (2019), conduct of the accreditation process (2025; accredited for 5 years, until August 2030).

• Member of the Academic Committee of the Doctoral Program in Food Science and Technology (2019 – 2022). Participation in the accreditation process (accredited for 5 years, 2022 – 2027).

• Member of the Academic Committee of the Master's Degree in Engineering Sciences with a mention in Chemistry (2018 – 2022). Participation in the accreditation process of the Program (2020 – 2021; accredited for 6 years, 2022 – 2028).

Departmental Level

• Deputy Director of Research and Postgraduate Studies, Department of Chemical Engineering and Bioprocesses, USACH (2014 – 2018).

• Head of Biotechnology Engineering, Department of Chemical Engineering and Bioprocesses, USACH (2012 – 2014).

• Director of the Food Biotechnology Laboratory, Department of Chemical Engineering and Bioprocesses, USACH (2007 – present)

National Committees and Advisories

• Member of the Hierarchization Commission, Faculty of Engineering and Sciences, Universidad Diego Portales, Chile (2023-present).

• Member of the Engineering 3 Study Group of FONDECYT (2010 – 2014, 2020).

• CORFO Project Evaluator.

• Evaluator of the ANID Associative Centers and Research Deputy Directorate.

• Evaluator of the ANID Human Capital Subdirectorate.

• Peer evaluator in accreditation processes of undergraduate and postgraduate careers (Acredita CI and Akredita QA).

• Advisor to companies in the food and pharmaceutical sector: Juvenescence US Corp (U.S.A.); Multifrut S.A. (Costa Rica); Biogarum S.A. (Chile); Jonathan Sprouts (U.S.A.).

• Member of the Hierarchization Commission of the Faculty of Engineering and Sciences of the Diego Portales University (2023 – present).

Events And Invited Conferences (Last 10 Years)

• Invited lecture "Biotechnological strategies to produce plant myrosinase: design and optimization of the process", II Meeting of Enzymes in Food, November 25 – 27, 2024, Valparaíso, Chile.

• Invited lecture "Biotechnological strategies to obtain broccoli myrosinase to maximize sulforaphane production", XII Latin American Congress of Medicinal Plants, August 28 – 30, 2024, Trujillo, Peru.

• President of the Organizing Committee of the IV Latin American Symposium on Biocatalysis and Biotransformations (IV SILAByB), November 8 – 11, 2022, Santiago, Chile.

• President of the Organizing Committee of the II Biocatalysis Conference, November 13 – 15, 2019, Santiago, Chile.

• Organizer of the International Seminar "Process Engineering and Functional Foods: Challenges and Opportunities to Valorize Natural Resources", University of Santiago de Chile, July 12, 2018, Santiago, Chile.

• Conference "Broccoli myrosinase production strategies for obtaining functional foods rich in sulforaphane", IV Latin American Symposium on Biocatalysis and Biotransformations (IV SILAByB), November 8 – 11, 2022, Santiago, Chile.

• Conference "Development of a dehydrated functional ingredient from the concept of scaling", Chilean Association of Chemical Engineering Students, October 26, 2020 (on-line).

• Conference "Purification, characterization and modeling of broccoli myrosinase for the design of an industrialization strategy in the field of functional foods", II Biocatalysis Conference, November 13 – 15, 2019, Santiago, Chile.

• Conference "Development of a dehydrated functional ingredient from concept to scaling", Second Specialized Technical Conference 2019 - CeTA: "Dehydration as a method of food preservation and ingredient development", April 16, Santiago, and July 10, 2019, Temuco, Chile.

• Conference "Purification, characterization and production of the broccoli myrosinase enzyme for its application in the food industry", 1st Congress of Enzymes in Food ENZAL, January 10, 2019, Santiago, Chile.

• Conference "Optimization of Pre- and Post-harvest Processing of Vegetables to maximize the content of Bioactive Compounds", University of Santiago de Chile, July 12, 2018, Santiago, Chile.

• Talk "Functional foods from the perspective of Chemical Engineering: Development and optimization of processes" X National Congress of Chemical Engineering Students, Santiago, November 8, 2016.

• Chair "Contribution of Chemical Engineering to the Development of Functional Foods in Chile", VI National Congress of Chemical Engineering Students, Santiago, October 24, 2012.

Graduate

• Subject "Methodology for Scientific Communication", a cross-disciplinary subject to all postgraduate programmes of the Faculty of Engineering and the Doctorate in Food Science and Technology. Taught in English.

• Subject "Advanced Food Biotechnology", Doctoral Program in Food Science and Technology and Master's Program in Food Technology.

• Subject "Bioseparation Processes", Doctoral Program in Engineering Sciences with a mention in Processes and Master's Program in Engineering Sciences with a mention in Chemistry.

Doctoral Thesis (Last 10 Years) 

• Máximo Coronado, "Development of a biotechnological process for obtaining sustainable and efficient recombinant bovine myoglobin, with potential application in the food industry", Doctoral Program in Food Science and Technology, University of Santiago de Chile (defense in 2027).

• Yipsy Arozarena, "Microencapsulation of sulforaphane using the oil-in-water emulsion method for incorporation into dairy producers", Doctoral Program in Food Science and Technology, University of Santiago de Chile (June 2025).

• Adielis Jiménez, "Research of a process of production, separation and purification of broccoli myrosinase expressed in Saccharomyces cerevisiae MGY70", Doctoral Program in Engineering Sciences with a mention in Processes, University of Santiago de Chile (December 2024).

• Raidel Comet, "Study and optimization of an unconventional extraction process to recover sulforaphane from enriched broccoli" PhD Program in Engineering Sciences with a mention in Processes, University of Santiago de Chile (2020).

• Juan Román, "Study of the molecular interaction of the broccoli myrosinase system with glucoraphanin and sinigrin, and its effect on enzyme activity", Doctoral Program in Food Science and Technology, University of Santiago de Chile (2018).

• Carmen Pérez, "Optimizing Broccoli Processing to Maximize Sulforaphane Content", PhD Program in Food Science and Technology, University of Santiago de Chile (2015).

Master's Thesis (Last 10 Years)

• Fernando Aro, "Physicochemical and kinetic characterization of recombinant broccoli myrosinase produced in Pichia pastoris", Master in Food Technology (defense in 2025).

• Víctor Zambrano, "Design and Optimization of a Sulforaphane Microencapsulation Process", Master's Program in Engineering Sciences with a mention in Chemistry (April 2021).

• Francis González, "Design of a Sulforaphane Extraction Process from Broccoli for Application in the Food Industry", Master's Program in Engineering Sciences with a mention in Chemistry (December 2020).

• María Belén Garzón, "Development of an extruded functional food rich in sulforaphane", Master's Program in Food Technology, University of Santiago de Chile (September 2017).

• Diego Catalán, "Application of the Finite Volume Method to Model the Chromatographic Purification of the Myrosinase Enzyme", Master's Program in Engineering Sciences with a mention in Chemistry, University of Santiago de Chile (October 2015).

• Carmen Pérez, "Optimization of the commercial broccoli blanching process to maximize sulforaphane formation", Master's Program in Food Technology, University of Santiago de Chile (October 2013).

• Jorge Pinto, "Optimization of convective drying of selenium-enriched broccoli", Master's Program in Engineering Sciences with a mention in Chemistry, Department of Chemical Engineering, University of Santiago de Chile (April 2012).

• Mauricio Zamorano, "Development of a functional broccoli-based food with enhanced anticancer and antioxidant properties", Master's Program in Food Technology, Department of Chemical Engineering, University of Santiago de Chile (April 2011).

Undergraduate

• Subject "Bioseparation Processes" (Civil) Engineering in Biotechnology.

• Subject: "Metabolic Engineering and Bioinformatics" (Civil) Engineering in Biotechnology.

• Subject "Thermodynamics", (Civil) Engineering in Biotechnology.

• Subject: "Bioprocess Analysis" (Civil) Engineering in Biotechnology.

• Subject "Bioprocess Pilot Plant" (Civil) Engineering in Biotechnology.

• Subject "Food Science I" Engineering (Civil and Execution) in Chemistry.

Thesis (Civil) Engineering In Biotechnology

• Camila Gallardo, "Scaling up the cultivation of Pichia pastoris for the production of recombinant myoglobin" (2023).

• Yarni Well, "Production of Recombinant Broccoli Myrosinase in Bacillus subtilis" (2023).

• Fernando Aro, "Comparison and evaluation of two recombinant broccoli myrosinase production systems" (2023).

• Cristian Erazo, "Heterologous expression of the myrosinase enzyme of Brassica oleracea var italica in Pichia Pastoris" (April 2021).

• Dorian González, "Structural, physicochemical and kinetic characterization of broccoli ESP and NSP proteins, for the design of a purification strategy" (April 2020).

• Constanza Martin, "Study and modeling of sulforaphane degradation during broccoli dehydration in a tunnel dryer" (January 2015).

• Natalia Loyola, "Effect of broccoli drying in a solar hybrid dryer on the content of bioactive compounds" (January 2015).

• Diego Catalán, "Modeling and simulation of the purification process of broccoli myrosinase" (January 2015).

• Alejandro Angulo, "Physicochemical and functional characterization of broccoli myrosinase for the design of a purification strategy" (April 2014).

• María Paz Rubio, "Study and modeling of the degradation kinetics of broccoli bioactive compounds during low-temperature storage" (April 2014).

• Ariel Orellana, "Design of a blood plasma fractionation process based on aqueous two-phase systems for its application in proteomics" (October 2013).

• Juan Román, "Study and optimization of the broccoli freeze-drying process to maximize sulforaphane content" (October 2013).

• Ivana Cofré, "Study and optimization of broccoli drying in a tunnel dryer to maximize sulforaphane content" (October 2013).

• Dafne Antoniz, "Dehydration of selenium-enriched broccoli by pulsating fluidized bed and evaluation of its antioxidant capacity in vivo", thesis for the degree of Biotechnology Engineer, Department of Chemical Engineering, University of Santiago de Chile (April 2012).

• Alejandra Martínez, "Effect of the administration of dehydrated selenized broccoli on the life expectancy, fecundity and antioxidant defense of C. elegans", thesis for the title of Biotechnology Engineer, Department of Chemical Engineering, University of Santiago de Chile (April 2012)

• Ignacio Sepúlveda, "Study of the effect of selenium fertilization on the metabolism of Brassica oleracea var. italica", thesis to apply for the title of Biotechnology Engineer, Department of Chemical Engineering, University of Santiago de Chile (September 2011).

Civil Engineering Thesis/Execution In Chemistry

• Nicolás Arriagada, "Development of healthy foods from the fruit of the michay (Berberis darwinii H.)" (October 2020).

• Constanza Córdova, "Scaling up and implementation of the production process of broccoli flour rich in bioactive compounds at the pilot level" (September 2018).

• Daniela Román, "Technical and Economic Feasibility Study of a Broccoli Meal Production Plant" (April 2018).

• Nicolás Lira, "Modeling the interaction between the broccoli myrosinase enzyme and molecules analogous to its substrate" (April 2018).

• Alejandro Andrade "Design and optimization of a process to obtain a baked food rich in sulforaphane" (August 2016).

• Mariela Miranda, "Optimization of broccoli pre-processing conditions to maximize sulforaphane content", thesis for the title of Chemical Execution Engineer, Department of Chemical Engineering, University of Santiago de Chile (October 2013).

• Paola Antoine, "Design of a process for obtaining dehydrated broccoli by convective drying", thesis for the title of Chemical Execution Engineer, Department of Chemical Engineering, University of Santiago de Chile (September 2010).

• Maritza Ismail, "Application of fractionation based on hydrophobicity of plasma proteins", thesis for the title of Civil Chemical Engineer, Department of Chemical Engineering, University of Santiago de Chile (September 2009).

• Jorge Riquelme, "Improvement of the production process of snail slime with high protein content of biotechnological interest" thesis to apply for the title of Civil Chemical Engineer, Department of Chemical Engineering, University of Santiago de Chile (April 2009).

• Wildo Cifuentes, "Optimization of proteomics performance by hydrophobic interaction chromatography", thesis for the title of Civil Chemical Engineer, Department of Chemical Engineering, University of Santiago de Chile (April 2009).

• Lya Salinas, "Research on the applicability of the PEG4000/phosphate system for the separation of highly abundant proteins in plasma", thesis for the title of Chemical Execution Engineer, Department of Chemical Engineering, University of Santiago de Chile (April 2009).

• Claudia Quilodrán, "Characterization and purification of two bioindicators of selenium functional status", Thesis for the title of Civil Chemical Engineer and Civil Engineer in Biotechnology, Department of Chemical Engineering and Biotechnology, University of Chile (January 2009).

• Mauricio Zamorano, "Application of hydrophobic interaction chromatography to the pre-treatment of biological samples for proteomic analysis", thesis for the title of Civil Chemical Engineer, Department of Chemical Engineering, University of Santiago de Chile (November 2008).

• Cristóbal Quintana, "Application of aqueous two-phase systems for the pretreatment of biological samples", thesis for the title of Chemical Execution Engineer, Department of Chemical Engineering, University of Santiago de Chile (October 2008).

• María Cristina Muñoz, "Development of a methodology for nutritional diagnosis and evaluation of the feasibility of patenting", thesis for the title of Civil Chemical Engineer, Department of Chemical Engineering, University of Santiago de Chile (October 2008).

• Iván Guzmán, "Development of a statistical model that describes the expression of nutritional bioindicators as a function of the characteristics of the diet", thesis to apply for the title of Chemical Execution Engineer, Department of Chemical Engineering, University of Santiago de Chile (April 2008).

• Patricio Pino, "Phenomenological modeling of a chromatographic column for purification of proteins of biomedical interest", thesis for the title of Civil Chemical Engineer, Department of Chemical Engineering, University of Santiago de Chile (April 2008).

• Gladys Navarro, "Methodologies for the identification of surface hydrophobic zones in proteins", Thesis for the title of Civil Engineer in Biotechnology, Faculty of Physical and Mathematical Sciences, University of Chile (July 2005).

Lines Of Research

Functional Foods:

• Development of dehydrated, vegetable-based functional ingredients naturally enriched in bio-active compounds, such as selene amino acids, isothiocyanates, polyphenols, glucosinolates and sulforaphane. Among the objectives of this line of research is the optimization of blanching and drying processes, to maximize the content of bio-active compounds in the final product; formulation of functional foods (baked, extruded, dehydrated), stability studies of bioactive compounds during storage, microencapsulation processes.

Protein Purification Processes:

• Design and optimization of processes to purify proteins or enzymes of interest to the food or pharmaceutical industry. Design of processes for the purification of metabolic bioindicator proteins (transthyretin), and enzymes of plant origin (myrosinase). Research in different protein purification operations in general, such as hydrophobic interaction chromatography and aqueous two-phase systems.

Fundamental Research Projects

National Competition

• ANID Project No 88240020 Doctoral Thesis in the Productive Sector: "Development of a biotechnological process for obtaining sustainable and efficient recombinant bovine myoglobin, with potential application in the food industry", as USACH institutional counterpart (2024 – 2026).

• Proyecto FONDECYT N°1201418: “Study and Optimization of a Process to obtain Recombinant Broccoli Myrosinase with Improved Catalytic Properties, with Potential Application in the Agro- Food Industry”, en calidad de Investigadora Responsable (2020 - 2023).

• PAI Project No 77170008 "Strengthening of Research in Food Biotechnology of the Department of Chemical Engineering" (Institutional Counterpart) (2018 – 2021).

• Proyecto de Investigación FONDECYT N° 1130384: “Study and optimization of a process to obtain dehydrated sulforaphane-rich broccoli intended to be a functional food”, en calidad de Investigadora Responsable. (2013 – 2017).

• FONDECYT Post-Doctoral Project N° 3130601 "Optimization of the cultivation and processing of broccoli sprouts to maximize the concentration of phenolic compounds, glucosinolates and sulforaphane", as Sponsor (2012 – 2014).

• Proyecto de Investigación FONDECYT N°1110101: “Theoretical and experimental analysis of a hybrid solar dryer using a phase-change material for energy storage”, en calidad de Co-Investigadora (2011 – 2014).

• Proyecto de Investigación FONDECYT N° 1100437: “Study and optimization of a process to obtain dehydrated Se-enriched broccoli with improved anticarcinogenic and antioxidant properties”, en calidad de Investigadora Responsable (2010 – 2012).

• FONDECYT Research Project No. 1061154: "Effect of dietary supplementation with organic selenium on the blood proteome: Identification of new bioindicators of the metabolic status of selenium", as Principal Investigator (2006 – 2009).

Internal Competition

• DICYT Project No. 082111MO_AYUDANTE "Design and optimization of an efficient process of microencapsulation of sulforaphane extracted from broccoli seeds to stabilize the compound in food formulations", Principal Investigator (2019).

• DICYT Project N°092011SF "Comparative phenomenological modeling of water desalination processes: Balance of matter, energy and transport mechanisms applied to thermal and membrane technologies", as Co-Investigator (2020 - 2022).

• Research Assistant Project 081911MO_PAP "Study of a Scalable Process to Produce Broccoli Myrosinase Expressed in E. coli", as Principal Investigator (2019).

• Postdoctoral Project 081911MO_POSTDOC "Physicochemical and functional characterization of broccoli ESP and NSP proteins for the design of a purification strategy", as Sponsor (2019 – 2020).

• Research Network Formation Project 031811MO_RED "Formation of a Research Network in Functional Foods and Nutraceuticals to Strengthen the Research Capacities of the University of Santiago de Chile" (Principal Investigator) (2018).

• DICYT Project code 081711MO "Study and optimization of an unconventional sulforaphane extraction process from broccoli" (Principal Investigator) (2017 – 2019).

• Vridei Project 021711MO_PUBLIC "Increasing the content of bioactive compounds in broccoli through fertilization and post-harvest processing" (Principal Investigator) (2017).

• DICYT Research Project N° 020911MO: "Optimization of hydrophobic interaction chromatography for its application in proteomics", as Principal Investigator (2009).

Applied Research Projects

National Competition

• Project FONDEF IDEA ID25|10038 “Validation of SFN-rich microcapsules as functional ingredient with demonstrated effectiveness for its use in the food industry”, as Director (2025 – 2027).

• Project FONDEF IDEA ID25I10163 “Innovation in atmospheric freeze-drying: Electrotechnologies to improve the quality and durability of dehydrated products”, as researcher (2025 – 2027)

• CORFO Project "Join to Innovate – Reactívate" 22SN-214338 "Sustainable trophic incorporation of micronutrients and trace elements in the national diet: Production of vegetable shoots for feeding hens producing functionalized eggs for human consumption", as Principal Investigator (2022).

• Fondef Idea Project ID22I10173 "Development of a new bactericide based on lytic bacteriophages, for the biological control of bacterial cancer in cherry trees and bacterial freckle in tomatoes, diseases caused by pseudomonas syringae", as an Alternate Researcher (2022 - 2024).

• CORFO Project "Join Innovation" 19SN-117596 "Development of new healthy foods from michay fruits (Berberis Darwinii H.) to improve the competitiveness of the Greenovation company by taking advantage of underexploited native resources", as Principal Investigator (2019).

• FONDEF IDeA Project Second Stage ID15l20589 "Characterization and design of new bacterial biofungicides for the control of gray cluster rot in table and wine vines, caused by the phytopathogenic fungus Botrytis cinerea", as an Alternate Researcher. (2020 - 2022).

• Innovation Project "Healthy Foods" PYT-2018-0316 "Valorization of broccoli and its by-products by optimizing its cultivation to produce an extract rich in sulforaphane and antioxidants that is applicable as a nutraceutical" (Alternate Researcher) (2018 – 2020).

• CORFO Project Line 2 Technological Contracts "Implementation and validation of the technology to produce on a pilot scale a functional ingredient based on broccoli flour for the food industry" 17CONTEC-83647 (Principal Investigator) (2017 – 2019). 

• R+D PROJECT FONDEF – VIU N° 140008: "Production and encapsulation of the broccoli myrosinase enzyme for its application as a food supplement", as Sponsor (2014).

• R+D PROJECT FONDEF – VIU N° 140018: "Formulation of instant soup from freeze-dried broccoli with high sulforaphane content as a functional food", as Sponsor (2014).

• Applied R + D Project CORFO 11IDL1-10623: "Valorization of a by-product of the brewing industry through the production of enriched yeast for human consumption", as Co-Investigator (2011).

Internal Competition

• Proyecto Puente DGT “Optimization of a process to obtain a SFN-rich extract from broccoli agroindustry discards for its use as dietary supplement with validated healthy effect”, Investigadora Responsable (2023 – 2024).

• Research, Development and Innovation Project DGT 021012-MO: "Physical, chemical and microbiological characterization of a functional food rich in selenium with improved antioxidant properties for human and animal use", as Principal Investigator (2011).

• Research, Development and Innovation Project DGT 021011-MO: "Development of a functional food rich in selenium with improved antioxidant properties for human and animal use", as Principal Investigator (2010).

• Research, Development and Innovation Project DGT08-2007: "Non-invasive and low-cost analytical methodology to determine the metabolic status of organic forms of selenium in mammalian organisms", as Principal Investigator (2009).

Scientific Articles In Indexed Journals

1. Fernando Aro, Cristian Erazo, Adielis Jiménez, Antonio Castillo, Andrea Mahn *. SUBMITTED to HELIYON http://dx.doi.org/10.2139/ssrn.4935596 

2. Juan Román, Aline Lagos, Andrea Mahn, Julián Quintero, “The Effect of Broccoli Glucosinolates Hydrolysis Products on Botrytis cinerea: A Potential New Antifungal Agent”, International Journal of Molecular Sciences 2024, 25(14) 7945, https://doi.org/10.3390/ijms25147945. (Q1, IF 5.6).

3. Darinka Radovic, Ziomara Gerdtzen, Maite González, Andrea Mahn, Karin Saavedra. Medidas afirmativas para mujeres en Stem: Análisis comparado de su implementación en universidades chilenas. Calidad en la Educación, 59, diciembre 2023, 191 – 232. https://doi.org/10.31619/caledu.n59.1382 (Scielo).

4. Víctor Zambrano, Rubén Bustos, Yipsy Arozarena, Andrea Mahn*. Optimization of a Microencapsulation Process using Oil-in-Water (O/W) Emulsion to Increase Thermal Stability of Sulforaphane. Foods, 2023 12(20), 3869. https://doi.org/10.3390/foods12203869 (Q1, IF=5.1).

5. Andrea Mahn*, Carmen Pérez, Víctor Zambrano, Herna Barrientos. Maximization of Sulforaphan Content in Broccoli Sprouts by Blanching. Foods, 2022, 11, 1906. https://doi.org/10.3390/foods11131906 (Q1, IF=5.1).

6. Adielis Jiménez, Antonio Castillo, Andrea Mahn. Kinetic Study and Modeling of Wild-Type and Recombinant Broccoli Myrosinase Produced in E. coli and S. cerevisiae as a Function of Substrate Concentration, Temperature, and pH. Catalysts 2022, 12, 683. https://doi.org/10.3390/catal12070683 (Q2; IF=3.9).

7. Carolina Curiqueo, Andrea Mahn, Antonio Castillo. Broccoli myrosinase expression in Escherichia coli and Saccharomyces cerevisiae. Biomolecules, 2022, 12, 233. https:// doi.org/10.3390/biom12020233. (Q1, IF=5.4).

8. Andrea Mahn*, Luis A. Segura-Ponce, Raidel Comett, Rodrigo Díaz-Álvarez. Effect of Pulsed Electric Fields – Assisted Extraction on Sulforaphane Recovery from Broccoli Florets. Journal of Food Process Engineering 2021, Vol 45, Issue 7, e13837. https://doi.org/10.1111/jfpe.13837 (Q2, IF=2.9).

9. Francis González, Julián Quintero, Rodrigo Del Río, Andrea Mahn*. Optimization of an extraction process to obtain a food-grade sulforaphane-rich extract from broccoli (Brassica oleracea var. italica). Molecules, 2021, 26, 4042. https://doi.org/10.3390/molecules26134042 (Q2, IF=4.6).

10. Aldo Saavedra*, Hugo Valdés *, Andrea Mahn, Orlando Acosta. Comparative analysis of conventional and emerging technologies for seawater desalination: northern Chile as a Case Study. Membranes (2021), 11, 180. https://doi.org/10.3390/membranes11030180 (Q2, IF=3.6).

11. Andrea Mahn, Antonio Castillo. “Potential of Sulforaphane as a Natural Immune System Enhancer: A Review”, Molecules (2021), 26, 752. https://doi.org/10.3390/molecules26030752 (Q2, IF=4.6).

12. Katherin V. Pereyra; David C. Andrade; Camilo Toledo; Karla Schwarz; Atenea Uribe-Ojeda1; Angélica P. Ríos-Gallardo; Andrea Mahn; Rodrigo Del Rio, “Dietary supplementation of a sulforaphane-enriched broccoli extract protects the heart from acute cardiac stress”, Journal of Functional Foods 75 (2020): 104267 https://doi.org/10.1016/j.jff.2020.104267 (Q2, IF=4.6).

13. Constanza Córdova, Juan P. Vivanco, Julián Quintero, Andrea Mahn, “Effect of drum drying conditions on the content of bioactive compounds of broccoli pulp”, Foods (2020) 9, 1224. https://doi.org/10.3390/foods9091224 (Q1, IF=5.1).

14. Andrea Mahn, Julián Quintero, Noelia Castillo, Raidel Comet, “Effect of ultrasound-assisted blanching on myrosinase activity and sulforaphane content in broccoli florets” Catalysts (2020) 10 616. https://doi.org/10.3390/catal10060616  (Q2, IF=3.9).

15. Julián Quintero, Daniela Román, José Salazar, Andrea Mahn, “Economic assessment of a small-scale plant for production of sulforaphane-rich broccoli flour in Chile”, Biofuels, Bioproducts & Biorefining (2020) 14:544-552. https://doi.org/10.1002/bbb.172 (Q2, IF=3.9).

16. Juan Román, Dorian González, Mario Inostroza, Andrea Mahn, “Molecular modeling of pithiospecifier and nitrile-specifier proteins of broccoli and their interaction with aglycones”, Molecules 2020 (25) 772. https://doi.org/10.3390/molecules25040772 (Q2, IF=4.6).

17. Víctor Zambrano, Rubén Bustos, Andrea Mahn, “Insights about stabilization of sulforaphane through microencapsulation”, Heliyon 5 (2019) e02951. DOI: https://doi.org/10.1016/j.heliyon.2019.e02951 (Q1, IF=3.9).

18. Alejandro Reyes, José Vásquez, Nicolás Pailahueque, Andrea Mahn, “Effect of drying using solar energy and phase change material on kiwifruit properties”, Drying Technology (2019) 37(2): 232 . 244, https://doi.org/10.1080/07373937.2018.1450268 (Q3, IF=3.2).

19. Andrea Mahn, Aldo Saavedra, María Paz Rubio, “Kinetic Study of Sulforaphane Stability in Blanched and Un-blanched Broccoli (Brassica oleracea var. italica) Florets during Storage at Low Temperatures” Journal of Food Science and Technology (2018) 55(11), 4687-4693. https://doi.org/10.1007/s13197-018-3395-4 (Q2, IF=3.8).

20. Juan Román, Antonio Castillo, Andrea Mahn, “Molecular Docking of Potential Inhibitors of Broccoli Myrosinase”, Molecules (2018) 23, 1313. https://doi.org/10.3390/molecules23061313 (Q2, IF=4.9). 

21. Juan Román, Luis Cottet, Antonio Castillo, Andrea Mahn, “Kinetic and structural study of broccoli myrosinase and its interaction with glucoraphanin and sinigrin”, Food Chemistry 254 (2018) 87 - 94. https://doi.org/10.1016/j.foodchem.2018.01.179 (Q1, IF=8.2).

22. Juan Román, Antonio Castillo, Luis Cottet, Andrea Mahn, “Molecular modeling of broccoli myrosinase and its interaction with different ligands”, Chemical Engineering Transactions (2018) 64: 373 - 378. https://doi.org/10.3303/CET1864063 (SCOPUS).

23. Andrea Mahn, María Paz Rubio, “Evolution of total polyphenols content and antioxidant activity in broccoli florets during storage at different temperatures”, Journal of Food Quality 2017 (2017) Article ID 3742183, 9 pages, https://doi.org/10.1155/2017/3742183 (Q3, IF=3.5).

24. Andrea Mahn, “Modeling of the effect of selenium fertilization on the content of bioactive compounds in broccoli heads”, Food Chemistry 233 (2017) 492 – 499. https://doi.org/10.1016/j.foodchem.2017.04.144 (Q1, IF=8.6).

25. Andrea Mahn, Carmen Pérez, Alejandro Reyes, “Efecto de las Condiciones de Secado en lecho Fluidizado Pulsante sobre el Contenido de Sulforafano de Brócoli”, Información Tecnológica 28 (4) (2017). http://dx.doi.org/10.4067/S0718-07642017000400004 

26. Andrea Mahn and Carmen Pérez, “Optimization of an incubation step to maximize sulforaphane content in pre-processed broccoli”, Journal of Food Science and Technology (2016) 53(11) 4110 – 4115 https://doi.org/10.1007/s13197-016-2386-6 (Q2, IF=3.8).

27. Andrea Mahn, Constanza Martin, Alejandro Reyes, Aldo Saavedra, “Evolution of sulforaphane content in sulforaphane-rich broccoli during tray drying”, Journal of Food Engineering 186 (2016) 27 - 33 https://doi.org/10.1016/j.jfoodeng.2016.04.007 (Q1, IF=5.7).

28. Andrea Mahn, Juan Román, Alejandro Reyes, “Efecto de la liofilización de brócoli pre-procesado sobre la cinética de secado y el contenido de sulforafano”, Información Tecnológica 27(6) 95 – 106 (2016) http://dx.doi.org/10.4067/S0718-07642016000600010 

29. José Vásquez, Alejandro Reyes, Andrea Mahn, Francisco Cubillos, “Evaluation of Fuzzy Control implemented in a Solar Dryer with Thermal Energy Storage System”, Drying Technology (2015) 34(13) 1558 – 1566 https://doi.org/10.1080/07373937.2015.1137001 (Q2, IF=3.3).

30. A. Reyes, A. Mahn, V. Cares, “Analysis of Dried Onions in a Hybrid Solar Dryer, Freeze Dryer and Tunnel Dryer”, Chemical Engineering Transactions, V 43, (2015) 139-144. https://doi.org/10.3303/CET1543024 

31. Andrea Mahn, Alejandro Angulo, Fernanda Cabañas, “Purification and Characterization of Broccoli (Brassica oleracea var italica) Myrosinase (β-thioglucosidase glucohydrolase)”, Journal of Agricultural and Food Chemistry (2014) 62 (48) 1666-1671. https://doi.org/10.1021/jf504957c (Q1, IF=6.3).

32. Alejandro Reyes, Daniela Negrete, Andrea Mahn, Francisco Sepúlveda, “Design and evaluation of a heat exchanger that uses paraffin wax and recycled materials as solar energy accumulator”, Energy Conversion & Management Volume 88, December 2014, Pages 391–398. https://doi.org/10.1016/j.enconman.2014.08.032 (Q1, IF=10.3).

33. Alejandro Reyes, Andrea Mahn, Francisco Vásquez, “Mushrooms dehydration in a hybrid solar dryer using a phase change material”, Energy Conversion & Management (2014) 83:241–248. https://doi.org/10.1016/j.enconman.2014.03.077 (Q1, IF=10.3).

34. Herna Barrientos, Carmen Pérez, Gustavo Zúñiga, Andrea Mahn, “Effect of methyl jasmonate, sodium selenate, and chitosan as exogenous elicitors on the phenolic compounds profile of broccoli sprouts”, Journal of the Science of Food and Agriculture (2014) 94(12): 2555-2561. https://doi.org/10.1002/jsfa.6596 (Q1, IF=4.2).

35. Carmen Pérez, Herna Barrientos, Juan Roman, Andrea Mahn, “Optimization of a blanching step to maximize sulforaphane synthesis in broccoli florets”, Food Chemistry 145 (2014) 264-271. DOI http://dx.doi.org/10.1016/j.foodchem.2013.08.053 (Q1, IF=8.6).

36. Alejandro Reyes, Andrea Mahn, Pedro Huenulaf, Tamara González, “Tomato dehydration in a Hybrid solar dryer”, Journal of Chemical Engineering & Process Technology (2014) 5: 4. https://doi.org/10.4172/2157-7048.1000196 

37. Alejandro Reyes, Francisco Cubillos, Andrea Mahn, Jose Vasquez, “Dehydration of Agro Products in a Hybrid Solar Dryer controlled through a Fuzzy Logic System”, International Journal of Modern Nonlinear Theory and Application (2014) 3: 66-76.  http://dx.doi.org/10.4236/ijmnta.2014.33009 

38. Andrea Mahn, Mauricio Zamorano, Alejandro Reyes, “Effect of freeze-drying conditions on antioxidant compounds of broccoli”, Food Processing & Technology (SCOPUS) (2014) 5: 360. https://doi.org/10.3390/foods9091224

39. Ignacio Sepulveda, Herna Barrientos, Alejandra Moenne, Andrea Mahn, “Changes in SMSeC, glucosinolates and sulforaphane levels, and in proteome profile in Broccoli (Brassica oleracea var. italica) fertilized with sodium selenate”, Molecules (2013) 18: 5221 - 5234; https://doi.org/10.3390/molecules18055221 (Q2, IF=4.9)

40. Alejandro Reyes, Andrea Mahn, Francisco Cubillos, Pedro Huenulaf, “Mushroom dehydration in a hybrid-solar dryer”, Energy Conversion and Management (2013) 70: 13-19. https://doi.org/10.1016/j.enconman.2013.01.032 (Q1, IF=10.3).

41. Alejandro Reyes, Natalia Pérez, Andrea Mahn. “Specific heat and thermal conductivity of “loco” (concholepas concholepas)”, Food and Bioprocess Technology: An International Journal; https://doi.org/10.1007/s11947-011-0698-0 Volume 6, Issue 7 (2013), Page 1873-1877. (Q1, IF=5.8).

42. Andrea Mahn, M. Elena Lienqueo, Claudia Quilodrán, Alvaro Olivera-Nappa, “Purification of transthyretin as nutritional biomarker of selenium status”, Journal of Separation Science (2012) 35: 3184 - 3189.  https://doi.org/10.1002/jssc.201200646 

43. Alejandro Reyes, Andrea Mahn, Carolina Guzmán, Dafne Antoniz, “Analysis of the drying of broccoli florets in a fluidized pulsed bed”, Drying Technology: an International Journal 30 (2012) 1368 - 1376. https://doi.org/10.1080/07373937.2012.686548 

44. Andrea Mahn, Alejandro Reyes, “An overview of health-promoting compounds of broccoli (Brassica oleracea var italica) and the effect of processing”, Food Science and Technology International 18 (6) 2012: 503 – 514. https://doi.org/10.1177/1082013211433073 

45. A. Mahn, M. Zamorano, H. Barrientos, A. Reyes, “Optimization of a process to obtain selenium-enriched freeze-dried broccoli with high antioxidant properties”, LWT – Food Science and Technology 47 (2012) 267 – 273. https://doi.org/10.1016/j.lwt.2012.01.017.

46. M.E. Lienqueo, A. Mahn, J.C. Salgado, C. Shene, “Mathematical Modeling of Protein Chromatograms”, Chemical Engineering and Technology (2012) 35: 46-57. https://doi.org/10.1002/ceat.201100282.

47. Valeri Bubnovich, Alejandro Reyes, Andrea Mahn, Esteban Quijada, “Numerical simulation of lyophilization of carrot slices at atmospheric pressure in a fluidized bed”, Journal of Food Engineering (2012) 109: 659 - 667. https://doi.org/10.1016/j.jfoodeng.2011.11.030.

48. A. Mahn, M. Ismail, “Depletion of highly abundant proteins in blood plasma by ammonium sulfate precipitation for 2D-PAGE analysis”, Journal of Chromatography B (2011) 879: 3645-3648. https://doi.org/10.1016/j.jchromb.2011.09.024.

49. Alejandro Reyes, Natalia Pérez, Andrea Mahn, “Theoretical and experimental study of freeze-drying of “loco” (Concholepas concholepas)”, Drying Technology (2011) (29) 3: 1386 - 1395. https://doi.org/10.1080/07373937.2011.586479. 

50. Alejandro Reyes, Andrea Mahn, Pedro Huenulaf. “Drying of apple slices in atmospheric and vacuum freeze-drier”, Drying Technology (2011) 29(9): 1076 - 1089. https://doi.org/10.1080/07373937.2011.568657. 

51. Alejandro Reyes, Agnes Evseev, Andrea Mahn, Valeri Bubnovich, Ruben Bustos, Eric Scheuermann. “Effect of operating conditions in freeze-drying on the nutritional properties of blueberries”, International Journal of Food Sciences & Nutrition (2011), 62(3): 303-306. https://doi.org/10.3109/09637486.2010.534078.

52. Andrea Mahn, Paola Antoine, Alejandro Reyes. “Optimization of drying kinetics and quality parameters of broccoli florets”, International Journal of Food Engineering (2011), Vol 7 Issue 2, art 14 (https://doi.org/10.2202/1556-3758.2181).

53. A.Mahn; H. Barrientos; A. Moenne; A. Reyes. “Optimizacion de las propiedades antioxidantes del brocoli mediante fertilizacion con selenio”. Biological Research (2011) 44 (SA): R175 https://doi.org/10.3390/pr11103037 

54. A. Mahn; I. Sepulveda; H. Barrientos. “Efecto de la fortificación con selenato de sodio sobre el metabolismo de Brassica oleracea”. Biological Research (2011) 44 (SA): R104.

55. Andrea Mahn, A. Reyes, M. Zamorano, W. Cifuentes, M. Ismail. “Depletion of highly abundant proteins in blood plasma by hydrophobic interaction chromatography for proteomic analysis”, Journal of Chromatography B 878 (2010): 1038 - 1044. https://doi.org/10.1016/j.jchromb.2010.03.006. 

56. Andrea Mahn, Herna Barrientos, Jeannette Vera, Alejandra Moenne, “Efecto de la fertilización con selenato de sodio sobre la actividad de myrosinasa y selenocisteina metiltransferasa en Brassica oleracea var. Italica”, Biological Research 43 Supl. A (2010): R-64.

57. Andrea Mahn, Juana Codoceo, Jorge Inostroza, Manuel Ruz, “Efecto de la suplementación dietaria con Se-metil selenocisteina y selenato de sodio sobre los índices metabólicos de selenio en ratas”, Biological Research 43 Supl. A (2010): R-64.

58. Andrea Mahn, M. Cristina Muñoz, Mauricio Zamorano. “Discovery of biomarkers that reflect the intake of sodium selenate by nutritional proteomics”, Journal of Chromatographic Science 47: 840 - 843 (2009) (ISI factor 1.000) https://doi.org/10.1093/chromsci/47.9.840.

59. Andrea Mahn, Héctor Toledo and Manuel Ruz. “Organic and inorganic selenium compounds produce different protein patterns in the blood plasma of rats”, Biological Research (2009) 42: 163 – 173. http://dx.doi.org/10.4067/S0716-97602009000200004 

60. Andrea Mahn, M. Elena Lienqueo, J. Cristian Salgado. “Methods of calculating protein hydrophobicity and their application in developing correlations to predict hydrophobic interaction chromatography retention”, Journal of Chromatography A 1216 (2009): 1838 - 1844. https://doi.org/10.1016/j.chroma.2008.11.089 

61. Andrea Mahn, Héctor Toledo, Manuel Ruz. “Dietary supplementation with selenomethylselenocysteine produces a differential proteomic response”, Journal of Nutritional Biochemistry 20 (2009) 791–799. https://doi.org/10.1016/j.jnutbio.2008.07.008 

62. Andrea V. Mahn. “Modelación Fenomenológica de Cromatografía de Interacción Hidrofóbica”, Información Tecnológica 2009 (20) 3: 135 – 144. http://dx.doi.org/10.4067/S0718-07642009000300015 

63. A. Mahn and M. Zamorano, “Agotamiento de las proteínas altamente abundantes en plasma sanguíneo de ratas mediante cromatografía hidrofóbica para análisis proteómico”, Biological Research 41 Supl. A (2008): R-107.

64. A. Mahn and H. Toledo, “Compuestos selenados orgánicos e inorgánicos producen distintas respuestas proteómicas en el plasma sanguíneo de ratas”, Biological Research 41 Supl. A (2008): R-153. http://dx.doi.org/10.4067/S0716-97602009000200004 

65. A. Mahn, L. Salinas and C. Quintana, “Agotamiento de albúmina en plasma mediante sistemas de dos fases acuosas como pretratamiento para análisis proteómico”, Biological Research 41 Supl. A (2008): R-108.

66. A. Mahn, H. Toledo, A. Tittarelli, M. Ruz. “Efecto de la suplementación dietaria con selenio orgánico sobre el proteoma plasmático de rata”, Biological Research 40 Sup. A (2007): R-148. http://dx.doi.org/10.4067/S0716-97602007000300007 

67. A. Mahn, A. Tittarellli*, R. Rincón, M. Ruz, H. Toledo. “Suplementación dietaria con selenio: Identificación de nuevos bioindicadores metabólicos”, Biological Research 40 (2007) Sup. 1: R-79.

68. M. Elena Lienqueo, Andrea Mahn, J. Cristian Salgado, Juan A Asenjo. “Current insights on the protein behavior on hydrophobic interaction chromatography”, J Chromatogr. B 849 (2007): 53 - 68. https://doi.org/10.1016/j.jchromb.2006.11.019

69. Andrea Mahn, M. Elena Lienqueo, Juan A. Asenjo. “Optimal operation conditions for protein separation in hydrophobic interaction chromatography”, J Chromatogr B 849 (2007): 236 – 242. https://doi.org/10.1016/j.jchromb.2006.09.013 

70. Andrea Mahn, M. Elena Lienqueo, Juan A. Asenjo. “A simple method for the estimation of protein retention in hydrophobic interaction chromatography under different operation conditions”, The Open Biotechnology Journal 2007 (1): 9 – 13 (ISSN No: 1874 - 0707). https://doi.org/10.2174/1874070700701010009 

71. M.E. Lienqueo, A. Mahn, G. Navarro, J.C. Salgado, T. Perez-Acle, I. Rapaport and J.A. Asenjo, “New Approaches for Predicting Protein Retention Times in HIC”, Journal of Molecular Recognition 2006 19(4):260-9.

72. Andrea Mahn, M. Elena Lienqueo, “Use of automated docking for predicting chromatographic behavior of proteins in hydrophobic interaction chromatography”, J. Biotechnol. 2005; 118: S32 – S33.

73. Andrea Mahn, Gladys Navarro, Gerald Zapata, “Prediction of protein retention time in hydrophobic interaction chromatography using automated docking”, FEBS Journal 2005; 272: 514.

74. M. Elena Lienqueo, Andrea Mahn, "Predicting protein retention times in hydrophobic interaction chromatography", Chemical Engineering and Technology 2005, 28 (11): 1326 - 1334.

75. Andrea Mahn and Juan A. Asenjo, “Prediction of protein retention in Hydrophobic Interaction Chromatography”, Biotechnology Advances 2005; 23 (5): 359 – 368.

76. Andrea Mahn, Gerald Zapata-Torres and Juan A. Asenjo, "A Theory of Protein - Resin Interaction in Hydrophobic Interaction Chromatography", Journal of Chromatography A, 1066 (2005): 81 - 88.

77. Andrea Mahn, M. Elena Lienqueo, Juan Asenjo, “Effect of surface hydrophobicity distribution on retention of ribonucleases in hydrophobic interaction chromatography”, Journal of Chromatography A 1043 (2004): 47-55.

78. M.Elena Lienqueo, Liliana Vásquez, Andrea Mahn, Juan Asenjo, “Methodology for predicting the retention of proteins by hydrophobic interaction chromatography and its application to a cell extract”, Journal of Chromatography A 1009 (2003): 189-196.

79. M. Elena Lienqueo, Andrea Mahn, Juan Asenjo, “Mathematical correlations for predicting protein retention time in hydrophobic interaction chromatography”, Journal of Chromatography A 978 (2002): 71-79.

80. Sergio Bravo, Andrea Mahn, Carolina Shene, “Effect of the feeding strategy on Zymomonas mobilis CP4 fed-batch fermentations and mathematical modeling of the system”, Applied Microbiology and Biotechnology 54 (2000):487-493.

Book Chapters

• Varzakas T., Mahn A., Pérez C., Miranda M., Barrientos H. (2015 ebook, 2016 print). “Blanching”, en: “Handbook of Food Processing. Food Preservation”, edited by Theodoros Varzakas and Constantina Tzia, eBook ISBN: 978-1-4987-2176-9, print ISBN: 978-1-4987-2175-2, CRC Press, Boca Raton, Florida, U.S.A.

• Mahn, A. (2013). “Selenium and health: Discovering nutritional biomarkers”, en: “Chemical safety in food chain”, edited by Franco Pedreschi and Zuzana Ciesarova, ISBN: 978-1-62948-344-3 (e-Book), Nova Science Publisher Inc., New York.

• Mahn, A.V. (2012). “Hydrophobic Interaction Chromatography: Fundamentals and Applications in Biomedical Engineering”, en: "Biomedical Engineering / Book 3", ISBN 978-953-307-556-3, INTECH Open Access Publisher, Croatia.

• Antoine P, Reyes A, Mahn A (2011). "Development and Optimization of a Process to Obtain Dehydrated Broccoli with Enhanced Antioxidant Properties", in: "Binational Meetings of Young Researchers of the Argentine-Chilean Bicentennial / Encuentro Centro", ISBN: 978-987-27982-3-9, Secretariat of University Policies, Buenos Aires, Argentina.

Patents Granted

• Andrea Mahn, Alejandro Reyes, Alejandro Andrade, "Functional food baked with broccoli rich in sulforaphane", application No. 3485 of 29 of 12 of 2017. (Application No. 201703485, Publication CL2017003485A1) GRANTED, Registration No.: 64844, date of assignment: 8 – 7- 2022.

• Andrea Mahn, Alejandro Reyes, Juan Román, "Process to increase the content of sulforaphane in broccoli", INAPI, application No. 3484 of 29 of 12 of 2017 (Application No. 201703484, Publication CL2017003484A1) GRANTED. Registration No. 64094. Assignment Date: 21 – 3 – 2022.

• Andrea Mahn, “Method for analyzing and determining the metabolic state of trace elements in mammals, based on the protein profile associated with a supra-nutritional metabolic state of the trace elements and the protein pattern”, Organización Mundial de la Propiedad Intelectual (oficina internacional), solicitud WO 2012/162852 A3, publicada el 6-12-2012, N° de proioridad US14/123,451, N° de registro (PCT/14/03/2019), CONCEDIDA (14/3/2019).

• Andrea Mahn, "PROCEDURE TO PREPARE AN ELECTROPHORETIC PROTEIN STANDARD OF REFERENCE IDENTIFYING BIOMARKERS RELATED TO THE NUTRITIONAL STATUS OF SELENIUM", INAPI, application 201101319, published on 02 – 06 – 2011, Registration No. 57133 (14/03/2019), GRANTED.

• Andrea Mahn, “Biomarkers related with a supra-nutritional metabolic state of selenium and diagnosis method in which said biomarkers are identified”, US20140332384A1; Date of Patent: Sept. 19, 2017, (GRANTED).

Patents Applied For

• Andrea Mahn, Víctor Zambrano, Yipsy Arozarena, "SULFORAPHANE (SFN) MICROENCAPSULATION METHOD TO STABILIZE IT AND EMULSION, MICROCAPSULES AND ADDITIVE" Application number 202303326, dated 8-11-2023, INAPI (Chile).

• 2025 Nominated to L’Oreal – UNESCO For Women in Science International Award 2026.

• 2024 Finalist "Ada Byron" Award for Technological Women in Chile, UNAB – University of Deusto, Spain.

• 2010 "Henri Nestlé 2010 Scientific Version Award – mention in Nutrition", Nestlé – Chile. "III Creativity, Innovation and Patenting Contest" Award, Directorate of Technologica Management, University of Santiago de Chile.

• 2004 Doctoral Thesis Completion Grant, Scientific and Technological Research Commission (CONICYT).

• 2003 Scholarship to attend international conferences, Commission of Scientific and Technological Research (CONICYT).

• 2002 Scholarship to attend international conferences, Commission of Scientific and Technological Research (CONICYT).

• 2001 - 04 Scholarship for doctoral studies, Commission for Scientific and Technological Research (CONICYT).

• 1999 Universidad de la Frontera Award for the Best Student of Food Engineering, University of la Frontera Temuco, Chile

Main Presentations at International Conferences

1. Mahn A, Comet R, Segura-Ponce, LA, Díaz-Álvarez, RE, “Effect of pulsed electric fields on sulforaphane recovery from broccoli florets”, 4th International Conference on Food and Biosystems Engineering, May 30th – June 2nd 2019, Heraklion, Greece.

2. Mahn A, González F, Román J, Contreras S, del Río, R, “Optimization of a process to obtain sulforaphane-rich extract from broccoli for its use in the food industry”, 4th International Conference on Food and Biosystems Engineering, May 30th – June 2nd 2019, Heraklion, Greece.

3. Román J., Mahn A., Castillo A., Cottet L., Lira N. “Molecular modeling of broccoli myrosinase and study of its interaction with different ligands”, International Conference on Industrial Biotechnology, 15 – 18 de abril de 2018, Venecia, Italia.

4. Román J., Castillo A., Cottet L., Mahn A. “Kinetics study of broccoli myrosinase”, 19th International Conference on Enzyme, 7 -8 de agosto de 2017, Vancouver, Canadá.

5. Andrea Mahn, Juan Román, Alejandro Reyes, “Effect of freeze-drying conditions of broccoli on drying kinetics and sulforaphane content”, International Conference on Nutraceuticals and Functional Foods, 6 – 9 julio 2016, Kalamata, Grecia. (ISBN for eBook 978-972-98998-5-0)

6. Andrea Mahn, María Paz Rubio, “Study and modeling of the loss of bioactive compounds in broccoli during storage at low temperature”, International Conference on Nutraceuticals and Functional Foods, 6 – 9 julio 2016, Kalamata, Grecia. (ISBN for eBook 978-972-98998-5-0)

7. Andrea Mahn, Juan Román, Alejandro Reyes, Carmen Pérez, “Optimización de un Proceso para obtener Brócoli Liofilizado con alto Contenido del Anticancerígeno Sulforafano” XXVII Congreso Interamericano y Colombiano de Ingeniería Química, Cartagena, Colombia, Octubre 6 – 8, 2014. ISBN: 978-958-58438-0-6.

8. Andrea Mahn; Carmen Pérez; Mariela Miranda and Herna Barrientos, “Effect of blanching conditions on sulforaphane content in purple and Roman cauliflower”, 3rd International Conference and Exhibition on Nutrition & Food Sciences, September 22-25, 2014, Valencia, Spain.

9. Andrea Mahn, Ivania Cofré and Alejandro Reyes, “Optimization of convective drying of broccoli to maximize the content of sulforaphane”, 3rd International Conference and Exhibition on Nutrition & Food Sciences, September 22-25, 2014, Valencia, Spain.

10. Carmen Pérez; Herna Barrientos; Mariela Miranda; Andrea Mahn, “Effect of blanching conditions on sulforaphane content in brócoli”, International Conference on Food and Biosystems Engineering, 30 mayo – 2 junio 2013, Skiathos, Greece.

11. Andrea Mahn; Alejandro Reyes; Dafne Antoniz, “Dehydration of selenium – enriched broccoli in a pulsed fluidized – bed dryer”, Sixth Nordic Drying Conference, 5 – 7 junio 2013, Copenhagen, Dinamarca.

12. Mahn, A.; Perez, C.; Barrientos, H.; Miranda, M., “Efecto del escaldado sobre la sintesis de sulforafano en coliflor morado y rumanesco”, 14° Congresso Latino-Americano de Cromtatografia e Tecnicas Relacionadas, 1 – 5 Octubre 2012, Florianópolis, Brazil.

13. Mahn, A.; Barrientos, H.; Perez, C., “Efecto de la fortificacion con selenio sobre la concentracion de sulforafano y selenometilselenocisteina en brócoli”, 14° Congresso Latino-Americano de Cromtatografia e Tecnicas relacionadas, 1 – 5 Octubre 2012, Florianópolis, Brazil. 

14. Mahn, A.; Zamorano, M.; Cartes, P.; Reyes, A., “Effect of freeze-drying conditions on antioxidant compounds of brócoli”, 2012 EFFoST Annual Meeting, 20 – 23 Noviembre 2012, Montpellier, France.

15. Mahn, A.; Reyes, A.; Antoniz, D.; Zamorano, M., Pinto, J., “Evaluation of different drying systems to obtain a broccoli-based funtional ingredient”, 2012 EFFoST Annual Meeting, 20 – 23 Noviembre 2012, Montpellier, France.

16. A. Mahn, M. Zamorano, W. Cifuentes, M. Ismail, “Depletion of highly-abundant proteins in blood plasma by hydrophobicity-based separation techniques”, 16th Internacional Conference on Biopartitioning and Purification - BPP2011, September, 18-22, 2011, Puerto Vallarta, Mexico.

17. A. Mahn; A. Reyes; M. Zamorano; P. Antoine; C. Guzman, “Effect of dehydration conditions on the content to antioxidant and anticarcinogenic compounds in brócoli”, XXV Interamerican Congress of Chemical Engineering, 14 – 17 Noviembre 2011, Santiago, Chile.

18. I. Sepulveda; H. Barrientos; A. Mahn, “Efecto de la fortificacion con selenio sobre el proteoma de brassica oleracea var. italica”, XXV Interamerican Congress of Chemical Engineering, 14 – 17 Noviembre 2011, Santiago, Chile.

19. M. Zamorano; A. Reyes; A. Mahn, “Effect of freeze-drying conditions on antioxidant properties of Se- enriched brócoli”, XXV Interamerican Congress of Chemical Engineering, 14 – 17 Noviembre 2011, Santiago, Chile.

20. A.Mahn; M. Zamorano, A. Reyes, “Optimization of the freeze-drying of broccoli florets”, XXXV Congresso Brasileiro de Sistemas Particulados, 23 – 16 Octubre 2011, Vassouras, Brazil.

21. I. Sepúlveda, H. Barrientos, A. Mahn, “Effect of fortification with selenium on the proteome of Brassica oleracea var. italica”, 16th Internacional Conference on Biopartitioning and Purification - BPP2011, September, 18-22, 2011, Puerto Vallarta, Mexico.

22. Paola Antoine, Alejandro Reyes, Andrea Mahn, “Desarrollo y optimización de un proceso para obtener brócoli deshidratado con propiedades antioxidantes mejoradas”, Encuentro Binacional de Jóvenes Investigadores del Bicentenario Chileno-Argentino - Zona Centro, 3 – 4 de Noviembre de 2010, Valparaíso, Chile.

23. A. Mahn, M. Ruz, H. Toledo “Effect of dietary supplementation with Se-methylselenocysteine and sodium selenate on the blood plasma proteome in rats”, XV Congreso Latinoamericano de Nutrición, 15 - 19 de Noviembre de 2009, Santiago, Chile.

24. A. Mahn, M. Ruz, H. Toledo and R. Vega, “Cancer chemoprotection through selenium: A nutriproteomics approach to identify selenium biomarkers”, Trace Elements in Men and Animals – TEMA 13, November 2008, Pucón, Chile.

25. A. Mahn, H. Toledo, "Discovery of biomarkers that reflect the intake of organic and inorganic selenium compounds through proteomics”, COLACRO XII, October 2008, Florianopolis, Brasil.

26. A. Mahn, M. Zamorano, “Depletion of highly abundant proteins in blood plasma by hydrophobic interaction chromatography for proteomic analysis”, COLACRO XII, October 2008, Florianopolis, Brasil.

27. A. Mahn and G. Díaz, “Cancer chemoprevention through dietary supplementation with organic forms of Selenium”, International Congress on Engineering and Food – ICEF 10, April 2008, Viña del Mar, Chile.

28. A. Mahn, F.A. Cubillos, J.M. Casas, “Modelación fenomenológica de una columna cromatográfica de interacción hidrofóbica para separación de proteínas”, XXXIII Congreso Brasilero de Sistemas Particulados – ENEMP2007, Octubre 2007, Sergipe, Brasil.

29. A. Mahn*, M.E. Lienqueo, G. Zapata – Torres, G. Navarro, J.A. Asenjo, “Retention time prediction in Hydrophobic Interaction Chromatography based on a protein’s surface hydrophobicity”, Internacional Conference on Biopartitioning and Purification BPP 2007, June 2007, Lisbon, Portugal.

30. A. Mahn*, M. Ruz, A. Olivera – Nappa, “Identification of nutritional biomarkers using proteomics and bioinformatics”, International Workshop of Collaborative Bioinformatics, Junio 2007, Málaga, España.

31. M.E. Lienqueo, A. Mahn, J.C. Salgado, I. Rapaport, J. A. Asenjo; “Predicting protein retention time in hydrophobic interaction chromatography”, 16th Biennial Meeting of the International Society for Molecular Recognition (Affinity 2005), August 2005, Uppsala, Sweden.

32. A. Mahn*, G. Navarro and G. Zapata, "Prediction of Protein Retention Time in Hydrophobic Interaction Chromatography using Automated Docking", 30th FEBS Congress, July 2005, Budapest, Hungary.

33. A. Mahn*, Zapata G. and Asenjo J.A., "A Theory of Protein – Resin Interaction in Hydrophobic Chromatography", 12th International Biotechnology Symposium and Exhibition Biotechnology 2004 (IBS2004), Octubre 2004, Santiago, Chile

34. M. E. Lienqueo*, J. M. S. Cabral, C. R. C. Calado, A. Mahn and O. Salazar, "Effect of peptide tags on protein retention in Hydrophobic Intraction Chromatography", European Symposium of Biochemical Engineering Science (ESBES – 5), Septiembre de 2004, Stuttgart, Alemania.

35. A. Mahn*, Lienqueo M.E., Asenjo J.A., “Effect of surface hydrophobicity distribution on protein retention in Hydrophobic Interaction Chromatography”, 23rd International Symposium on the Separation of Proteins, Peptides and Polynucleotides (ISPPP - 2003) realizado entre los días 9 y 12 de Noviembre de 2003 en Delray Beach, Florida, USA.

36. Lienqueo M.E.*, Olivera A., Mahn A., Asenjo J.A., “Validation of correlation for predicting protein retention time in hydrophobic interaction chromatography: case of protein with unknown 3D structure”, 11th European Congress on Biotechnology, desarrollado entre los días 19 y 24 de Agosto de 2003 en Basel, Suiza.

37. A. Mahn, J. A. Asenjo and M.E. Lienqueo*, “Optimal conditions for protein purification using Hydrophobic Interaction Chromatography”, International Symposium on the Separation of Proteins, Peptides and Polynucleotides (ISPPP – 2002) efectuado en Heidelberg, Alemania, entre el 9 y el 13 de Noviembre de 2002.

38. Mahn, A.V.*, Lienqueo, M.E., and Asenjo, J.A. “Prediction of Protein Retention Time in Hydrophobic Interaction Chromatography: Validation of Mathematical Correlations”, European Symposium of Biochemical Engineering Science (ESBES – 4), August 2002, Delft, The Netherlands.

39. M.E. Lienqueo*, A.V. Mahn y J.A. Asenjo “Mathematical Correlations for Predicting Protein Retention Time in Hydrophobic Interaction Chromatography", International Symposium on the Separation of Proteins, Peptides and Polynucleotides (ISPPP-2001), November 2001, Orlando, Florida, USA.

40. Lienqueo M.E., A.V. Mahn and J.A. Asenjo*, “Evaluation of the Hydrophobicity of Proteins for Predicting Retention Time in Hydrophobic Interaction Chromatography", BIOCHEMICAL ENGINEERING XII: Back to the Future, Application of Biochemical Engineering Fundamentals to Modern Problems, June 2001, California, U.S.A.

41. Bravo S., A. Mahn, C. Shene*, "Efecto de la Estrategia de Alimentación en la Velocidad de Producción de Biomasa en Fermentaciones Fed - Batch de Zymomonas mobilis", XVIII Congreso Interamericano de Ingeniería Química, Noviembre 1998, San Juan, Puerto Rico.

Main Presentations at National Conferences

1. A. Andrade, A. Mahn, "Design and optimization of a process to obtain a baked food with a high sulforaphane content", XX Chilean Congress of Chemical Engineering, May 14 – 17, 2017, Santiago, Chile.

2. J. Román, A. Mahn, "Modeling of the enzymatic kinetics of broccoli myrosinase", XX Chilean Congress of Chemical Engineering, May 14 – 17, 2017, Santiago, Chile.

3. A. Mahn, M.B. Garzón, "Development of an extruded functional food rich in sulforaphane", XX Chilean Congress of Chemical Engineering, May 14 – 17, 2017, Santiago, Chile.

4. A. Mahn, M.P. Rubio, "Modeling of sulforaphane degradation kinetics in broccoli during low- temperature storage", XX Chilean Congress of Chemical Engineering, May 14 – 17, 2017, Santiago, Chile.

5. N. Lira, A. Mahn, M. Inostroza, "Molecular modeling of the broccoli myrosinase enzyme for the study of interaction with its substrate and analogous molecules", XX Chilean Congress of Chemical Engineering, May 14 – 17, 2017, Santiago, Chile.

6. J. Román, A. Mahn, "Kinetic characterization of the myrosinase-sinigrin and myrosinase- glucoraphanin systems of broccoli", LIX Annual Meeting of the Society of Biology of Chile, November 8 – 10, 2016, Concón, Chile.

7. J. Román, H. Barrientos, A. Mahn, "Study of the Storage of Broccoli Flour Enriched in Sulforaphane and its Application as a Functional Ingredient in Instant Soups", XXI Congress of Nutrition, December 2 – 5, 2015, Concepción, Chile.

8. A. Mahn, J. Román, "Characterization of the glucosinolates profile of cruciferous vegetables grown in the central zone of Chile", LVIII Annual Meeting of the Society of Biology of Chile, November 23 – 25, 2015, Puerto Varas, Chile.

9. A. Mahn, A. Angulo, "Purification and preliminary characterization of broccoli myrosinase (β- thioglucosidase glucohydrolase)", LVIII Annual Meeting of the Chilean Biological Society, November 23 – 25, 2015, Puerto Varas, Chile.

10. J. Román, A. Mahn, "Study and optimization of the broccoli freeze-drying process to maximize sulforaphane content", XIX Chilean Congress of Chemical Engineering, October 15 – 17, 2014, Concepción, Chile.

11. D. Catalán, A. Mahn, "Modeling and optimization of a chromatographic process for myrosinase purification", XIX Chilean Congress of Chemical Engineering, October 15 – 17, 2014, Concepción, Chile.

12. A. Mahn; D. Antoniz; J. Palacios; A. Martínez; C. Guzmán, "Development and validation of a functional food rich in selenium", XIX Congress of Nutrition, 23 – 26 November 2011, Coquimbo, Chile.

13. A. Mahn; H. Barrientos; A. Moenne; A. Reyes, "Optimization of the antioxidant properties of broccoli through selenium fertilization", LIV Annual Meeting of the Society of Biology of Chile, 6 – 9 November 2011, Puerto Varas, Chile.

14. A. Mahn; I. Sepúlveda; H. Barrientos, "Effect of Sodium Selenate Fortification on the Metabolism of Brassica oleracea", LIV Annual Meeting of the Chilean Society of Biology, 6 – 9 November 2011, Puerto Varas, Chile.

15. Andrea Mahn, Juana Codoceo, Jorge Inostroza, Manuel Ruz, "Effect of dietary supplementation with Semethyl selenocysteine and sodium selenate on selenium metabolic indices in rats", LIII Annual Meeting of the Biological Society of Chile, November 21 – 24, 2010, Santa Cruz, Chile.

16. Andrea Mahn, Herna Barrientos, Jeannette Vera, Alejandra Moenne, "Effect of sodium selenate fertilization on myrosinase and selenocysteine methyltransferase activity in Brassica oleracea var. Italica", LIII Annual Meeting of the Society of Biology of Chile, November 21 – 24, 2010, Santa Cruz, Chile.

17. M. Zamorano, F. Cubillos, A. Mahn, "Applicability of the theoretical dish model to the simulation of hydrophobic interaction chromatography (HIC)", XVII Chilean Congress of Chemical Engineering, October 25 – 28, 2009, Viña del Mar, Chile.

18. A. Mahn, L. Salinas and C. Quintana, "Albumin depletion in plasma by aqueous two-phase systems as a pretreatment for proteomic analysis", LI Meeting Society of Biology of Chile, 26 – 29 November 2008, Pucón, Chile.

19. A. Mahn and H. Toledo, "Organic and inorganic selenated compounds produce distinct proteomic responses in the blood plasma of rats", LI Meeting of the Society of Biology of Chile, 26 – 29 November 2008, Pucón, Chile.

20. A. Mahn and M. Zamorano, "Depletion of highly abundant proteins in rat blood plasma by hydrophobic chromatography for proteomic analysis", LI Meeting Society of Biology of Chile, 26 – 29 November 2008, Pucón, Chile.

21. A. Mahn, A. Tittarellli*, R. Rincón, M. Ruz, H. Toledo. "Dietary Supplementation with Selenium: Identification of New Metabolic Bioindicators", 50th Annual Meeting of the Society of Biology of Chile, Pucón, November 21 – 24, 2007.

22. A. Mahn, H. Toledo, A. Tittarelli, M. Ruz. "Effect of dietary supplementation with organic selenium on the plasma proteome of rats", 50th Annual Meeting of the Society of Biology of Chile, Pucón, November 21 – 24, 2007.

23. A. Mahn* and J. M. Casas, "Phenomenological Modeling of the Water Softening Process through an Ion Exchange Column" XV Chilean Congress of Chemical Engineering (CIQ 2002), Punta Arenas, October 22 - 25, 2002.

24. Lienqueo M.E.*, Mahn A.V. and Asenjo J.A., "Optimization of the operating conditions of Hydrophobic Interaction Chromatography (HIC) for protein purification" XV Chilean Congress of Chemical Engineering (CIQ 2002 Punta Arenas, October 22 - 25, 2002.

25. A. Mahn*, S. Bravo, C. Shene, "Effect of Operating Conditions on Fed-batch Fermentations of Zymomonas mobilis CP4 on Kinetic Parameters", XIV Chilean Congress of Chemical Engineering (CIQ 2000), October 23 - 27, 2000, Santiago.